DOI: 10.1007/s12017-016-8429-3 Pages: 69-80
Article Type: Original Paper

Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations

1. University of Thessaly, University Hospital of Larissa, Laboratory of Neurogenetics, Department of Neurology, Faculty of Medicine

2. General Hospital of Larissa, Intensive Care Unit

3. University of Thessaly, University Hospital of Larissa, Department of Neurosurgery

4. University of Athens, School of Medicine, “Attikon” University Hospital, Second Department of Neurology

5. St. Anne’s University Hospital in Brno, International Clinical Research Center

6. Aristotle University of Thessaloniki, Second Department of Neurosurgery, Hippokration University Hospital

7. Aristotle University of Thessaloniki, Department of Physiology

8. Papageorgiou General Hospital, Department of Neurology

9. University of Thessaly School of Medicine, Department of Biomathematics

10. Medical College Jagiellonian University, Department of Neurology

Correspondence to:
Georgios M. Hadjigeorgiou
Tel: + 30 241 350 2301
Email: gmhadji@med.uth.gr

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Abstract

Α limited number of genetic variants have been linked to the development of intracerebral hemorrhage (ICH). Ιntegrin AV and/or B8-deficient mice were found to develop ICH. The present candidate gene association study was designed to investigate possible influence of integrin AV (ITGAV) and integrin B8 (ITGB8) gene region polymorphisms on the risk of ICH. 1015 participants (250 Greek and 193 Polish patients with primary ICH and 250 Greek and 322 Polish controls) were included in the study. Using logistic regression analyses, 11 tag single nucleotide polymorphisms (SNPs) for ITGAV and 11 for ITGB8 gene were tested for associations with ICH risk, lobar ICH risk and non-lobar ICH after adjustment for age, gender, history of hypertension and country of origin. Linear regression models were used to test the effect of tag SNPs on the ICH age of onset. Correction for multiple comparisons was carried out. The rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in the codominant model of inheritance [odds ratio (95 % confidence interval (CI)) 0.56 (0.36–0.86), p = 0.0013]. Furthermore, heterozygous individuals of the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes [regression coefficient (b) −3.884 (95 % CI −6.519, −1.249), p = 0.0039 and b = −4.502 (95 % CI −7.159, −1.845), p = 0.0009, respectively]. The present study provides preliminary indication for an influence of ITGAV gene tag SNP in the development of lobar ICH and of ITGB8 gene variants in the age of ICH onset.

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  • Accepted: Jul 20, 2016
  • Online: Jul 30, 2016

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