DOI: 10.1007/s13311-016-0480-0 Pages: 199-211
Article Type: Original Article

Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model

1. Universidad de Cordoba, Departamento de Biologia Celular, Fisiologia e Inmunologia, Facultad de Veterinaria

2. Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC)

3. Universidad de Cordoba, Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina

4. Hospital Universitario Reina Sofía de Cordoba, Servicio de Neurología

5. Canvax Biotech SL

6. Universidad de Cordoba, Departamento de Ciencias Sociosanitarias y Radiologia y Medicina Fisica, Seccion de Psiquiatria, Facultad de Medicina

7. Universidad Autonoma del Estado de México, Departamento Neurofisiología de la Conducta, Facultad de Medicina

8. Universidad de Cordoba, Departamento de Ciencias Morfologicas, Seccion Histologia, Facultad de Medicina

9. Universidad Nacional Autonoma de Mexico (UNAM), Departamento de Neuropatologia Molecular, Instituto de Fisiologia Celular

10. Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad (RETICEF)

Correspondence to:
Isaac Túnez
Email: fm2tufii@uco.es

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Abstract

Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that altering certain bacterial populations present in the gut may lead to a proinflammatory condition, that could result in the development of multiple sclerosis (MS). Also, Reactive Oxygen Species seem to be involved in the course of MS. In this study, it has been aimed to relate all these variables starting from an analysis of the lipopolysaccharide (LPS) and LPS-binding protein (LBP) with the determination of parameters related to oxidative stress in the blood, brain and spinal cord. For this purpose, samples obtained from EAE rats and relapsing-remitting (RRMS) MS patients were used. In addition, EAE rats were treated with Natalizumab, N-acetyl-cysteine and dimethyl fumarate. Natalizumab was also employed in RRMS. The results of this study revealed an improvement in the clinical symptoms of the EAE and MS with the treatments, as well as a reduction in the oxidative stress parameters and in LBP. Correlations between the clinical variables of the disease, i.e. oxidative damage and LBP, were established. Although the conclusions of this research are indeed relevant, further investigation would be necessary to establish the intrinsic mechanisms of the MS-oxidative stress-microbiota relationship.

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  • Online: Oct 7, 2016

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